Expanded porphyrins. Functional photoacoustic imaging agents that operate in the NIR-II region

Synthesis of Binuclear Copper (II) Complexes with Expanded Porphyrins

The synthesis and characterization of some new binuclear copper (II) complexes, based on the use of large, pyrole-containing macrocycles, the so called "expanded porphyrins", [Cu2(macrocycle)]+4 is described. Electron Spin Resonance (ESR) studies indicate a weak "half-field line", which is characteristic of the Cu(II)-Cu(II) dimer, is observed at about 1600G. The obser...

Contrast agents for photoacoustic imaging

aturation effect in functional photoacoustic imaging

ao F. Zhang niversity of Wisconsin-Milwaukee epartment of Electrical Engineering and Computer Science 200 N Cramer Street ilwaukee, Wisconsin 53201 Abstract. We investigate the saturation effect, which describes the violation of the linearity between the measured photoacoustic amplitude and the object’s optical absorption coefficient in functional photoacoustic imaging when the optical absorpti...

Saturation effect in functional photoacoustic imaging.

We investigate the saturation effect, which describes the violation of the linearity between the measured photoacoustic amplitude and the object's optical absorption coefficient in functional photoacoustic imaging when the optical absorption in the object increases. We model the optical energy deposition and photoacoustic signal generation and detection in a semi-infinite optical absorbing obje...

Synthesis and Application of New Gadolinium-Porphyrins as Potential MR Imaging Contrast Agents for Cancer Detection in Nude Mice

Two new potential magnetic resonance imaging contrast agents, Gd-hematoporphyrin (Gd-H) and Gd-tetra-carboranylmethoxyphenyl-porphyrin (Gd TCP), were synthesized and applied to nude mice with human melanoma (MM 138) xenografts. These agents showed a high relaxivity because of their greater potential to coordinate water molecules. The reduction of T1 relaxation times of 16 and 21% was observed i...